I have written in this forum often about organization and neatness in the work environment. Whether you work from home or not, when you work in a messy area, your thoughts and energy will also be messy. When you are organized and your work setting is enjoyable, then your thoughts are more creative and organized as well.
There's more to it, though. You may be neat and organized but your work space is a basement corner, with cement block and no windows. Energetically, what does that do to you? Without natural light, your body and mind tire easily. Hard, dull concrete stifles your senses. You may feel enclosed, restricted. So, what can you do to change this energy?
If the basement corner is your best option in your home, you can still make your workspace pleasant. Use natural lightbulbs placed overhead, mimicking sun coming through a window. Keep fresh plants or flowers in the area. Place pleasing pictures around with lovely landscapes, to offer a "window" view. Get up and move around often to avoid feeling restricted.
The best option, or course, is to work in a more pleasant surrounding. If you can, move your workspace near a window for natural lighting, avoiding direct sunlight creating glare in your eyes or on your computer. Frequently look away from your computer out the window to give your eyes a break. Stand and stretch, and admire the view, even if it's just the street outside.
When you keep in mind that your environment affects your mood and your thoughts, you can ensure that you feel your best every time you're working.